TY - JOUR AU - Dwi Winarni PY - 2012/02/05 Y2 - 2026/06/19 TI - EFEK EKSTRAK AKAR GINSENG JAWA DAN KOREA TERHADAP LIBIDO MENCIT JANTAN PADA PRAKONDISI TESTOSTERON RENDAH JF - Berkala Penelitian Hayati JA - Berkala Penelitian Hayati VL - 12 IS - 2 SE - Articles DO - 10.23869/347 UR - https://www.berkalahayati.org/index.php/jurnal/article/view/347 AB - This research was designed to compare the potency and duration effect of Java ginseng and Korean ginseng root extract administration on sexual behavior of male mice. It was done experimentally on male mice (strain BALB, aged 8–10 weeks, weighed 25–35 g). Thirty eight mice were grouped to 4 (four) groups: First group was treated with solvent (as positive control), 2nd group was treated ethynilestradiol (EE2) (as negative control), 3rd group was treated with Java ginseng root extract, and 4th group was treated with Korean ginseng root extract. All groups were administered with EE2 0.56 mg/20 g bw/day for 9 days as pretreatment to decrease the testosteron level. After pretreatment, each group divided to 3 subgroups (each would receive treatment for 9, 18, and 27 days). Ethynilestradiol 0.56 mg/20 g bw/day was administered along treatment to keep testosterone level low, except to positive control group. Java ginseng and Korean ginseng root extract (equal with 1.4 mg ginseng root powder/ 20 g bw/day) and EE2 were administered orally. The level of testosterone after pretreatment was measured by RIA (radioimmuoassay) and changes in libido were determined by libido test. After the last treatment, 1 male mouse kept singly in individual cage. Libido test was carried out for 20 minutes. All of these activities during test recorded by handycam. The mice were observed for time from the introduction of female into the cage of male upto the first mount (mounting latency/ ML) and for the number of mounts (mounting frequency/MF). The results indicated that at low testosterone level, Java ginseng root extract administration at the dose equal with 1.4 mg ginseng root powder/20 g bw/day shortened mounting latency and increased mounting frequency but Korean ginseng extract root at the same dose gave negative effects. Duration of administration of both Java and Korean ginseng root extract didn’t give effect on libido. ER -

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      <depositor_name>Wulida Khoirunnisa</depositor_name>
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    <registrant>The East Java Biological Society</registrant>
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        <full_title>Berkala Penelitian Hayati</full_title>
        <abbrev_title>Berkala Penelitian Hayati</abbrev_title>
        <issn media_type="electronic">2337-389X</issn>
        <issn media_type="print">0852-6834</issn>
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          <month>01</month>
          <day>25</day>
          <year>2025</year>
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          <volume>31</volume>
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        <issue>1</issue>
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          <title>Effect of Spatholobus littoralis hassk extract on matrix metalloproteinase-1 and elastin fiber morphology in d-galactose-ınduced aging model rats</title>
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          <person_name contributor_role="author" sequence="first">
            <given_name>Luh Ade Lela</given_name>
            <surname>Arika</surname>
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            <surname>Harliansyah</surname>
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            <given_name>Puput Putuh </given_name>
            <surname>Anisa</surname>
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            <given_name>Nenden Lilis </given_name>
            <surname>Setiasih</surname>
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          <jats:p>This study was investigates the effects of ethanol extract of bajakah wood (Spatholobus littoralis Hassk) on skin aging with D-galactose-induced Sprague-Dawley rats, focusing on Matrix Metalloproteinase-1 (MMP-1) concentration and elastin fiber morphology. A total of 36 male rats were divided into six groups; I (Blank), II, III, IV, V and VI, receiving varying doses of the extract. MMP-1 levels were measured using an ELISA kit, while elastin fibers were assessed through Verhoeff Van Gieson staining. The results show that the extract indicated that the extract significantly inhibit MMP-1 activity, with group 2 exhibiting the highest concentration (35.78 ng/ml) compared to other groups (p = 0.039). Furthermore, the extract notably increased elastin fiber content, particularly in group 6 (100 mg/kgBB), which showed a mean percentage of 7.10% compared to 2.22% in the control group (p &lt; 0.001). Qualitative analysis revealed a more intense and evenly distributed brown coloration in higher-dose treatment groups, indicating enhanced elastin density. These findings suggest that bajakah wood extract possesses antioxidant and anti-inflammatory properties, making it a promising candidate for therapeutic interventions aimed at improving skin quality and combating age-related changes. By modulating MMP-1 activity and promoting elastin synthesis, the extract could serve as a valuable addition to skincare formulations. Future research should explore the specific mechanisms through which bajakah wood extract exerts its effects, as well as its long-term efficacy and safety in human applications, to fully realize its therapeutic potential.</jats:p>
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          <month>04</month>
          <day>12</day>
          <year>2025</year>
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