TY - JOUR AU - Ernanin Dyah Wijayanti AU - Nur Candra Eka Setiawan PY - 2017/12/19 Y2 - 2026/05/16 TI - The effect of lactic acid fermentation on fig (Ficus carica) fruit flavonoid JF - Berkala Penelitian Hayati JA - Berkala Penelitian Hayati VL - 23 IS - 1 SE - Articles DO - 10.23869/54 UR - https://www.berkalahayati.org/index.php/jurnal/article/view/54 AB - Fig fruit contains a quite high flavonoid that supports the use of it for several disease therapies. Yet, most of the flavonoid in plants is difficult to be digested since it bounds with the glycoside, so the hydrolysis is necessary. The hydrolysis can be done through the lactic acid fermentation. This research aims to determine the effect of lactic acid fermentation on fig fruit flavonoid. Dried fig fruit was prepared into a fig fruit extract and fermented at 37°C for 24 hours using 4 types of starter bacteria; Lactobacillus acidophilus, L. bulgaricus, L. casei and L. plantarum. The fermentation result was identified its flavonoid using dye reaction, determined its flavonoid content using the spectrophotometry with the quercetin standard, and analyzed qualitatively using the LC-MS/MS. The results show that the flavonoid was identified in both before and after the fermentation, but the flavonoid content decreases 30 – 50% after the fermentation. The LC-MS/MS shows that the identified flavonoid is rutin, with the relatively higher percentage after the fermentation. In addition, the catechin and epicatechin are not detected. It can be concluded that the lactic acid fermentation affects the fig fruit flavonoid. The fermentation with all types of starter bacteria decreases the total flavonoid content of fig fruit juice. ER -

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        <full_title>Berkala Penelitian Hayati</full_title>
        <abbrev_title>Berkala Penelitian Hayati</abbrev_title>
        <issn media_type="electronic">2337-389X</issn>
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          <day>25</day>
          <year>2025</year>
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          <title>Effect of Spatholobus littoralis hassk extract on matrix metalloproteinase-1 and elastin fiber morphology in d-galactose-ınduced aging model rats</title>
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          <person_name contributor_role="author" sequence="first">
            <given_name>Luh Ade Lela</given_name>
            <surname>Arika</surname>
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            <surname>Harliansyah</surname>
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            <given_name>Puput Putuh </given_name>
            <surname>Anisa</surname>
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            <given_name>Nenden Lilis </given_name>
            <surname>Setiasih</surname>
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          <jats:p>This study was investigates the effects of ethanol extract of bajakah wood (Spatholobus littoralis Hassk) on skin aging with D-galactose-induced Sprague-Dawley rats, focusing on Matrix Metalloproteinase-1 (MMP-1) concentration and elastin fiber morphology. A total of 36 male rats were divided into six groups; I (Blank), II, III, IV, V and VI, receiving varying doses of the extract. MMP-1 levels were measured using an ELISA kit, while elastin fibers were assessed through Verhoeff Van Gieson staining. The results show that the extract indicated that the extract significantly inhibit MMP-1 activity, with group 2 exhibiting the highest concentration (35.78 ng/ml) compared to other groups (p = 0.039). Furthermore, the extract notably increased elastin fiber content, particularly in group 6 (100 mg/kgBB), which showed a mean percentage of 7.10% compared to 2.22% in the control group (p &lt; 0.001). Qualitative analysis revealed a more intense and evenly distributed brown coloration in higher-dose treatment groups, indicating enhanced elastin density. These findings suggest that bajakah wood extract possesses antioxidant and anti-inflammatory properties, making it a promising candidate for therapeutic interventions aimed at improving skin quality and combating age-related changes. By modulating MMP-1 activity and promoting elastin synthesis, the extract could serve as a valuable addition to skincare formulations. Future research should explore the specific mechanisms through which bajakah wood extract exerts its effects, as well as its long-term efficacy and safety in human applications, to fully realize its therapeutic potential.</jats:p>
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          <month>04</month>
          <day>12</day>
          <year>2025</year>
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